Alzheimer's kab mob, ib qho kev puas siab puas ntsws neurodegenerative, tshwm sim los ntawm cov tsos mob xws li nco tsis tau, aphasia, agnosia, thiab kev ua haujlwm tsis zoo. Kev lig kev cai, cov neeg mob tau tso siab rau cov tshuaj rau cov tsos mob. Txawm li cas los xij, vim muaj kev txwv thiab muaj peev xwm tshwm sim ntawm cov tshuaj no, cov kws tshawb fawb tau tig lawv lub siab mus rau qhov tsis muaj qhov cuam tshuam ntawm phototherapy, ua tiav qhov tseem ceeb hauv xyoo tas los no.
Tsis ntev los no, ib pab neeg coj los ntawm Xib Fwb Zhou Feifan los ntawm Biomedical Engineering College ntawm Hainan University tau tshawb pom tias kev tsis sib cuag transcranial phototherapy tuaj yeem txo cov tsos mob ntawm tus kab mob thiab txhim kho kev txawj ntse hauv cov laus thiab Alzheimer's-kev txom nyem nas. Qhov kev tshawb pom no, luam tawm hauv phau ntawv Journal Nature Communications, muaj lub tswv yim zoo rau kev tswj cov kab mob neurodegenerative.
Nkag siab txog Alzheimer's Disease Pathology
Qhov laj thawj ntawm Alzheimer's tseem tsis tau paub meej, tab sis nws yog tus cwj pwm los ntawm kev txawv txav ntawm beta-amyloid protein aggregation thiab neurofibrillary tangles, ua rau neuronal dysfunction thiab kev txawj ntse poob. Lub hlwb, raws li lub cev feem ntau metabolically active organ, tsim cov metabolic pov tseg tseem ceeb thaum lub sij hawm neural ua si. Kev sib sau ntau dhau ntawm cov pov tseg no tuaj yeem ua rau cov neurons puas tsuaj, tsim kom muaj kev tshem tawm zoo los ntawm cov kab mob lymphatic.
Cov hlab ntsha meningeal lymphatic, tseem ceeb rau lub hauv paus paj hlwb, ua lub luag haujlwm tseem ceeb hauv kev tshem tawm cov tshuaj lom beta-amyloid proteins, metabolic pov tseg, thiab tswj kev tiv thaiv kab mob, ua rau lawv lub hom phiaj rau kev kho mob.
Phototherapy's Impact rau Alzheimer's
Xibfwb Zhou pab neeg tau siv 808 nm ze-infrared laser rau plaub lub lis piam ntawm kev tsis sib cuag transcranial phototherapy rau cov laus thiab Alzheimer's nas. Qhov kev kho mob no tau txhim kho kev ua haujlwm ntawm meningeal lymphatic endothelial hlwb, txhim kho lymphatic kua, thiab thaum kawg alleviated pathological tsos mob thiab txhim kho kev txawj ntse hauv cov nas.
Txhawb nqa Neuronal Function los ntawm Phototherapy
Phtotherapy tuaj yeem txhim kho thiab txhim kho kev ua haujlwm neuronal los ntawm ntau yam txheej txheem. Piv txwv li, cov txheej txheem tiv thaiv kab mob ua lub luag haujlwm tseem ceeb hauv Alzheimer's pathology. Cov kev tshawb fawb tsis ntev los no qhia tau hais tias 532 nm ntsuab laser irradiation tuaj yeem txhawb lub cev tiv thaiv kab mob ua haujlwm, ua rau cov txheej txheem hauv nruab nrab hauv nruab nrab neurons, txhim kho vascular dementia, thiab txhim kho cov ntshav txaus thiab cov tsos mob hauv cov neeg mob Alzheimer. Pib ntsuab laser vascular irradiation tau pom tias muaj kev txhim kho tseem ceeb hauv cov ntshav viscosity, plasma viscosity, ntshav liab sib sau ua ke, thiab kev ntsuam xyuas neuropsychological.
Liab thiab infrared lub teeb kho (photobiomodulation) siv rau peripheral lub cev thaj chaw (rov qab thiab ob txhais ceg) tuaj yeem qhib lub cev tiv thaiv kab mob los yog qia hlwb 'intrinsic tiv thaiv mechanisms, pab txhawb rau neuronal ciaj sia taus thiab muaj txiaj ntsig gene qhia.
Oxidative puas tsuaj kuj yog ib qho tseem ceeb ntawm cov txheej txheem pathological hauv Alzheimer txoj kev loj hlob. Kev tshawb fawb qhia tias lub teeb liab irradiation tuaj yeem ua rau muaj kev ua haujlwm ntawm tes ATP, ua rau muaj kev hloov pauv ntawm glycolysis mus rau mitochondrial kev ua haujlwm hauv inflammatory microglia cuam tshuam los ntawm oligomeric beta-amyloid, txhim kho cov tshuaj tiv thaiv microglia qib, txo cov pro-inflammatory cytokines, thiab activating phagocytosis los tiv thaiv neuronal. tuag.
Txhim kho kev ceeb toom, kev paub, thiab kev mloog zoo yog lwm txoj hauv kev los txhim kho Alzheimer tus neeg mob lub neej zoo. Cov kws tshawb fawb tau pom tias raug rau lub teeb xiav luv luv ua rau muaj txiaj ntsig zoo rau kev paub txog kev ua haujlwm thiab kev tswj hwm kev xav. Blue light irradiation tuaj yeem txhawb kev ua haujlwm ntawm neural circuit, cuam tshuam rau kev ua haujlwm ntawm acetylcholinesterase (AchE) thiab choline acetyltransferase (ChaT), yog li txhim kho kev kawm thiab kev nco muaj peev xwm.
Phototherapy's Positive Effects on Brain Neurons
Ib lub cev loj hlob ntawm kev tshawb fawb tau lees paub qhov kev kho mob zoo rau lub hlwb neuron muaj nuj nqi. Nws pab qhib lub cev tiv thaiv kab mob 'intrinsic tiv thaiv mechanisms, txhawb nqa neuronal ciaj sia taus noob qhia, thiab sib npaug mitochondrial reactive oxygen hom. Cov kev tshawb pom no tsim kom muaj lub hauv paus ruaj khov rau kev kho duab kho mob cov ntawv thov kho mob.
Raws li cov kev nkag siab no, MERICAN Optical Energy Research Center, koom tes nrog pab pawg German thiab ntau lub tsev kawm ntawv qib siab, kev tshawb fawb, thiab cov tsev kho mob, tau ua kev tshawb fawb txog cov tib neeg hnub nyoog 30-70 uas muaj kev puas siab ntsws me me, nco tsis tau, txo kev nkag siab thiab kev txiav txim siab, thiab txo qhov peev xwm kawm. Cov neeg koom nrog ua raws li kev noj zaub mov thiab kev noj qab haus huv cov txheej txheem kev noj qab haus huv thaum tab tom ua kev kho mob hauv MERICAN lub tsev noj qab haus huv, nrog rau hom tshuaj noj thiab ntau npaum li cas.
Tom qab peb lub hlis ntawm kev ntsuam xyuas neuropsychological, kev kuaj mob hlwb, thiab kev ntsuam xyuas kev paub, cov txiaj ntsig tau pom tias muaj kev txhim kho tseem ceeb hauv MMSE, ADL, thiab HDS cov qhab nia ntawm cov neeg siv kho mob hauv tsev kho mob. Cov neeg tuaj koom kuj tau ntsib kev pom kev zoo, pw tsaug zog zoo, thiab txo kev ntxhov siab.
Cov kev tshawb pom no qhia tias kev kho duab kho mob tuaj yeem ua haujlwm pabcuam kev kho mob los tswj lub hlwb kev ua haujlwm ntawm tes, txo qis neuroinflammation thiab lwm yam pathologies, txhim kho kev paub, thiab txhim kho kev nco. Ntxiv mus, nws qhib txoj hauv kev tshiab rau kev kho duab kho mob kom hloov mus rau hauv kev tiv thaiv kev kho mob.
